The FDA has issued a Drug Safety Communication (DSC) for consumers warning of allergic and adverse reactions to OTC products containing benzoyl peroxide and salicylic acid, ingredients commonly used in acne products. 44% of the 131 reports received from 1969-2013, required hospitalization from severe allergy symptoms which are usually seen within 24 hours. The FDA is considering requiring a warning on the labels of products containing these active ingredients.
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More info:
http://cosmetics.specialchem.com/news/industry-news/fda-issues-warning-against-potential-dangerous-side-effects-topical-acne-products